منابع مشابه
Kainate-induced uptake of calcium by synaptosomes from rat brain.
Kainic acid induces a rapid increase in 45Ca2+ uptake by crude synaptosomal fractions isolated from rat brain. This enhanced Ca2+ permeability occurs with a half-time of approx. 1 s, similar to the fast phase of depolarization-induced calcium uptake. The depolarization-induced uptake of calcium is inhibited 85% by 3 mM CoCl2, 80% by 100 microM quinacrine and 50% by 15 microM trifluoperazine whi...
متن کاملCorrelation between Brain Lesion Site and Fluent/Non-Fluent Aphasia
Background and purpose: Aphasia is the most common communication disorder resulting from stroke. In this condition all modalities of language, including reading, writing, auditory perception, and oral speech may be affected. Aphasia is divided into two categories: fluent (Wernicke's aphasia, Transcortical sensory aphasia, conduction aphasia, and anomic aphasia) and non-fluent (Broca's aphasia,...
متن کاملBrain lesion and AIDS.
BUMC PROCEEDINGS 2000;13:424–429 CASE PRESENTATION J. TODD GAGE, MD: A 32-year-old African American man with AIDS was brought to the emergency department of Baylor University Medical Center. Shortly before breakfast on the day of admission, the patient had abruptly lost consciousness and experienced a tonicclonic seizure, which lasted several minutes and resolved spontaneously. No head trauma, ...
متن کاملEffects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
BACKGROUND The cyclooxygenase-2 inhibitor nimesulide is able to reduce kainate-induced oxidative stress in vivo. Here we investigate if this effect is mediated by the direct antioxidant properties of nimesulide using a well-characterized in vitro model of kainate toxicity. RESULTS Exposure of rat brain homogenates to kainate (12 mM) caused a significant (p < 0.01) increase in the concentratio...
متن کاملMelatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions.
Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4 mM). The concentration of malonaldehyde and 4-hydro...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1996
ISSN: 0022-3069
DOI: 10.1097/00005072-199607000-00004